Case of mistaken identity leads to much-needed drug target against MRSA, gram-positive infections

Scientists have uncovered a pharmacological target that could enable development of novel drugs against antibiotic-resistant pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant enterococci (VRE) and other infectious Gram-positive organisms such as Listeria and Mycobacterium tuberculosis. The target was revealed upon discovery of a Gram-positive bacteria-specific pathway for making heme, an essential iron-carrying molecule.



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