Doctors find insulin dose not a risk factor for cardiovascular mortality

A double-blinded, randomized clinical trial came to a halt after patients receiving more intensive diabetes therapy were found to have a higher mortality rate, compared to the standard therapy. In 2008, the results were released, puzzling researchers. Subsequent investigations have not been able to clearly identify the exact reason for the increased mortality, although some previous epidemiologic and mechanistic studies did suggest that insulin may be associated with adverse cardiovascular outcomes.

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