New findings point to central nervous system role in painful diabetic peripheral nerve disease

The central nervous system is a key contributor to the problem of painful peripheral nerve disease in people with diabetes, emerging evidence suggests. Diabetic peripheral neuropathy (DPN) occurs in about one-half of all patients with diabetes. In addition to progressive and severe pain, patients with DNP have insensitivity to trauma, placing them at risk of foot ulcerations, infections, and amputations.

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